In a wide spectrum of diseases, IC plays a critical role in disease pathology by forming immune deposits in kidney glomeruli in lupus nehritis and blood vessel walls in vasculopathies. Formation of excessive membrane attack complex (MAC) leads to tissue necrosis. Our recent research have demonstrated that MAC can be associated to IC and subsequently can be transferred to the tissue with the help of
the exposed RGD sequence on vitronectin by the action of granzyme B and integrins expressed on the tissue (see proposed model, figure above). Thus removal of ICs via extracorporeal circuit will be a good approach for treating the refractory autoimmune diseases. The lack of availability of a commercial product on the market for selective removal of CIC from the plasma of patients presents an unmet need. |
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